Subject: AL
Envivo Bio, Inc.; Confidential
Figure 1 is an interactive figure showing the microbial community
composition in each collected sample. Here, each color and shade
corresponds to a different genus. For reference, domestic dogs
(Canis familiaris) and gray wolves (Canis lupus) are
different species that belong to the same genus (Canis).
You can interact with this figure by:
- Hovering the cursor over a color in the stacked bar to see the
taxonomic identity, sample type, and relative abundance corresponding to
that color and bar
- Clicking and dragging the cursor over a portion of the figure to
zoom
- Single-clicking a genus’s name in the legend to remove that genus
from the figure
- Double-clicking (very quickly) a genus’s name in the legend
to only show that genus
Figure 1: Microbial community composition of
collected saliva, stool, and CapScan samples. CapScan samples are
ordered from proximal to distal intestine (i.e.,
increasing distance from mouth). Taxonomic composition is reported at
the genus rank. Genera present at <1% relative abundance across all
samples are reported as “Other genera”. Note: Blue =
Firmicutes; Yellow = Actinomycetes; Green =
Bacteroidetes; Red = Proteobacteria; Purple = all
other phyla. Shades of the same color (except purple) correspond to
different genera from the same phylum.
Figure 2 is an interactive figure showing the microbial community
composition at higher taxononomic resolution. Here, each row corresponds
to a unique microbe.
You can interact with this figure by:
- Hovering the cursor over a cell to see that microbe’s genus and
species (and strain when available), relative abundance, and full
taxonomic classification
- Clicking and dragging the cursor over a portion of the figure to
zoom
Figure 2: Heat map showing relative abundance of
microbes in each sample (N = 266 total identified). Each row corresponds
to a unique microbe and each column corresponds to an individual sample.
Note the relative abundance colorscale is in log units.
1.3 Notable microbes detected
- Bacteroides:
- Production of proteases from a few different species linked to gut
inflammation, such as Bacteroides vulgatus (Mills et
al., 2022) and Bacteroides fragilis (Wu et al.,
2009)
- Note: Genera Bacteroides and Phocaeicola
are very closely related, with a recent reclassification of some
Bacteroides as Phocaeicola (García-López et
al., 2019). There are conflicting taxonomic assignments in this
dataset (e.g., genus identified as Phocaeicola but
strain listed under Bacteroides) – to help interpretation,
regard Bacteroides and Phocaeicola as
one genus.
1.4 References
García-López, M., Meier-Kolthoff, J.P., Tindall, B.J., Gronow, S.,
Woyke, T., Kyrpides, N.C., et al. (2019) Analysis of 1,000
Type-Strain Genomes Improves Taxonomic Classification of
Bacteroidetes. Front Microbiol 10: https://doi.org/10.3389/fmicb.2019.02083.
Mills, R.H., Dulai, P.S., Vázquez-Baeza, Y., Sauceda, C., Daniel, N.,
Gerner, R.R., et al. (2022) Multi-omics analyses of the
ulcerative colitis gut microbiome link Bacteroides vulgatus
proteases with disease severity. Nat Microbiol
7: 262–276.
Wu, S., Rhee, K.J., Albesiano, E.,
Rabizadeh, S., Wu, X., Yen, H.R., et al. (2009) A human colonic
commensal promotes colon tumorigenesis via activation of T helper type
17 T cell responses. Nat Med 15:
1016–1022.
---
title: "<br> Taxonomic profiling of bacterial and archaeal communities from saliva, stool, and CapScan-sampled gut metagenomes"
output:
  html_document:
    df_print: paged
    toc: true
    toc_float: true
  html_notebook: default
  pdf_document: default
---

---

<style>
div.highlight {
background-color: #F2F2F2;
padding: 0px;
border-radius: 2px;
}

</style>

### <b><i>Subject: AL</b></i>
*Envivo Bio, Inc.; Confidential*

```{r setup, include = FALSE}
knitr::opts_chunk$set(echo = TRUE)
```

```{r add logo, echo = FALSE}
logo_path <- "../logo/envivo.svg"

htmltools::img(src = knitr::image_uri(logo_path), 
               alt = "logo", 
               style = "position:absolute; top:0; right:0; padding:10px; width: 145px; height: 42px")
```

```{r load packages, include = FALSE}
# List required packages
cranPackages <- c("BiocManager", "ggplot2", "dplyr", "tidyr",
                  "ape", "ggplot2", "reshape2", "plotly", "heatmaply")
biocPackages <- c("phyloseq", "Biostrings")

# Install missing CRAN packages
installedCRAN <- cranPackages %in% rownames(installed.packages())
if (any(installedCRAN == FALSE)) {
  install.packages(cranPackages[!installedCRAN],
                   repos = 'http://cran.us.r-project.org')
}

# Install missing Bioconductor packages
installedBioc <- biocPackages %in% rownames(installed.packages())
if (any(installedBioc == FALSE)) {
  BiocManager::install(biocPackages[!installedBioc])
}

# Load packages
lapply(c(cranPackages, biocPackages), library, character.only = TRUE)
```

```{r load data, include = FALSE}
# Load CosmosID data and formatted metadata
cosmos <- read.csv(file = "../data/CP04618_follow_up_20220920.csv")
meta <- read.csv(file = "../data/CP04618_follow_up_metadata.csv")
```

```{r format data, include = FALSE}
# Prepare tax_table and otu_table objects
tax <- cosmos %>%
  select(Phylum, Class, Order, Family, Genus, Species, Strain) %>%
  as.matrix %>%
  tax_table

start_ind <- grep("Strain", colnames(cosmos))+1
stop_ind <- ncol(cosmos)-2
abundance_scores <- cosmos[,start_ind:stop_ind] %>% otu_table(., taxa_are_rows = TRUE)

# Reformat sample names and metadata sample names so they match
colnames(abundance_scores) <- colnames(abundance_scores) %>%
  gsub("X", "", .) %>%
  gsub("_.*", "", .) %>%
  paste0("EB_", .)

row.names(meta) <- meta %>%
  pull(Sample_number) %>%
  paste0("EB_", .)

sam_data <- sample_data(meta)
```

```{r build phyloseq, include = FALSE}
# Build phyloseq object
ps <- phyloseq(tax, abundance_scores, sam_data)
```

```{r transform data, include = FALSE}
# Log transform
psLog <- ps %>% transform_sample_counts(., function(x) log(x + 1, base = 10))

# Relative abundance transform
psRA <- ps %>% transform_sample_counts(., function(x) x/sum(x)*100)
```

```{r rank phyla, include = FALSE}
phy_rank <- psRA %>%
  tax_glom(., taxrank = "Phylum") %>%
  psmelt %>%
  group_by(Phylum) %>%
  summarise(median = median(Abundance))

phy_rank %>% arrange(desc(median))
```

```{r subject subset, include = FALSE}
# Set subject
subject <- "AL"

# Subset to subject samples and drop missing taxa
psSub <- subset_samples(ps, Subject == subject) %>%
  prune_taxa(taxa_sums(.) > 0, .)

# Add plot label for each sample
sample_data(psSub)$Plot_label <- paste0(sample_names(psSub), " (", sample_data(psSub)$Sample_type, ")")

# Relative abundance transform
psSub_ra <- psSub %>% transform_sample_counts(., function(x) x/sum(x)*100)
```

```{r plot bar, include = FALSE}
# Define NOT IN operator
'%!in%' <- function(x,y)!('%in%'(x,y))

# Agglomerate at Genus and melt
taxrank <- "Genus"
melt <- psSub_ra %>% tax_glom(., taxrank = taxrank) %>% psmelt

# Define major phyla
major_phy <- c("Firmicutes", "Actinobacteria", "Bacteroidetes", "Proteobacteria")

# Identify genera present in <1% relative abundance in all samples
rare_genera <- melt %>%
  group_by(Sample_number, Genus) %>%
  summarize(sum = sum(Abundance)) %>%
  ungroup() %>%
  group_by(Genus) %>%
  summarize(max = max(sum)) %>%
  filter(max < 1) %>%
  pull(Genus)

# Create new column containing name of genus if above cutoff or "Other genera" if not
df <- melt %>%
  mutate(Phy_group = case_when(Phylum %!in% major_phy ~ "Other phylum",
                               TRUE ~ Phylum),
         Phy_group = case_when(Genus %in% rare_genera ~ "Other phylum",
                               TRUE ~ Phy_group),
         Tax_label = case_when(Genus %in% rare_genera ~ "AaOther genera",
                               TRUE ~ Genus)) %>%
  group_by(Subject) %>%
  arrange(Subject, Sample_type)

# Define order
phy_order <- c("Other phylum",
               "Proteobacteria",
               "Bacteroidetes",
               "Actinobacteria",
               "Firmicutes") %>% rev

gen_order <- df %>%
  select(Phy_group, Tax_label) %>%
  mutate(Order = match(Phy_group, phy_order)) %>%
  arrange(Order, desc(Tax_label)) %>%
  distinct %>%
  pull(Tax_label)

gen_order <- factor(gsub("^Aa", "", gen_order), levels = gsub("^Aa", "", gen_order)) # the Aa is to make sure "Other" is plotted at the top

df <- df %>%
  mutate(Tax_label = factor(gsub("^Aa", "", Tax_label), levels = gen_order))

# Define colors
phy_color <- data.frame(Phylum = c("Actinobacteria",
                                   "Other phylum",
                                   "Bacteroidetes",
                                   "Firmicutes",
                                   "Proteobacteria"),
                        Base_color = c("#FFB724",
                                       "#832CFF",
                                       "#64C62A",
                                       "#072AC8",
                                       "#E93B4F"))

phy_color <- phy_color[match(phy_order, phy_color$Phylum),]

# Data frame as input, data frame with new column of hex codes as output
col_palette <- df %>%
  select(Phy_group, Tax_label) %>%
  distinct %>%
  mutate(Hex_code = NA)


for(phy in phy_color$Phylum) {
  test <- col_palette %>%
    filter(Phy_group == phy) %>%
    pull(Tax_label) %>%
    droplevels %>%
    levels
  
  tax.color <- colorRampPalette(c(phy_color$Base_color[match(phy, phy_color$Phylum)], "white"))
  coltest <- tax.color(length(test)+2) %>%
    .[-length(.)]
  col_palette$Hex_code[match(test, col_palette$Tax_label)] <- coltest
}

col_palette <- col_palette %>% arrange(factor(Tax_label, levels = gen_order))
```

<div class="highlight">
### 1.1 Overview of microbial community composition
</div>

Figure 1 is an interactive figure showing the microbial community composition in each collected sample. Here, each color and shade corresponds to a different genus. For reference, domestic dogs (*Canis familiaris*) and gray wolves (*Canis lupus*) are different species that belong to the same genus (*Canis*).
<br><br>
You can interact with this figure by:

* Hovering the cursor over a color in the stacked bar to see the taxonomic identity, sample type, and relative abundance corresponding to that color and bar
* Clicking and dragging the cursor over a portion of the figure to zoom
* Single-clicking a genus's name in the legend to remove that genus from the figure
* Double-clicking (<u>very quickly</u>) a genus's name in the legend to only show that genus
```{r, out.width = "100%", echo = FALSE}
# Plot
pBar <- plot_ly(df, x = ~Plot_label, y = ~Abundance, type = "bar",
             color = ~Tax_label, colors = col_palette$Hex_code,
             textposition = "none",
             text = ~paste("<b>Genus:</b>", Tax_label,
                           "<br><br>", "<b>Sample type:</b>", Sample_type,
                           "<br>", "<b>Relative abundance:</b>", paste0(round(Abundance, digits = 1), "%")),
             hoverinfo = "text") %>%
  layout(xaxis = list(title = "<b>Sample</b>",
                      ticks = "outside"),
         yaxis = list(title = "<b>Relative abundance (%)</b>",
                      ticks = "outside"),
         barmode = "stack",
         font = list(family = "Arial"))

pBar$x$layout$yaxis$linecolor <- "#000000"
pBar
```
**Figure 1:** Microbial community composition of collected saliva, stool, and CapScan samples. CapScan samples are ordered from proximal to distal intestine (*i*.*e*., increasing distance from mouth). Taxonomic composition is reported at the genus rank. Genera present at <1% relative abundance across all samples are reported as "Other genera". <u>Note:</u> Blue = *Firmicutes*; Yellow = *Actinomycetes*; Green = *Bacteroidetes*; Red = *Proteobacteria*; Purple = all other phyla. Shades of the same color (except purple) correspond to different genera from the same phylum.

```{r, include = FALSE}
# Ordination-based
pHeat_ord <- plot_heatmap(psSub_ra, method = "NMDS", distance = "bray",
                          taxa.label = "Strain",
                          max.label = 300)

# Retrieve row and taxon orders
row_order <- pHeat_ord$plot_env$taxa.order %>% rev
tax_order <- tax_table(psSub_ra)[match(row_order, rownames(tax_table(psSub_ra))),] %>%
  as.data.frame %>%
  mutate(taxon = rownames(.),
         Abundance = 1,
         Sample = subject)
```

```{r, include = FALSE}
# Prepare data
x <- psSub_ra %>% otu_table %>% as.data.frame
colnames(x) <- lapply(colnames(x), grep, sample_data(psSub_ra)$Plot_label, value = TRUE) %>% unlist

# Add taxonomy
x <- cbind(x, tax_table(psSub_ra))

# Reorder rows and columns to match ordination
x <- x[match(row_order, rownames(x)),]

# Set hovertext
nsamp <- nsamples(psSub_ra)
hover_strain <- x[, 1:nsamp]
hover_strain[] <- paste0("<b>Microbe:</b> ", x$Strain, "\n",
                         "<b>Relative abundance:</b> ")
hover_strain <- as.matrix(hover_strain)

hover_abund <- x[, 1:nsamp] %>% round(., digits = 2) %>% as.data.frame
hover_abund <- apply(hover_abund, 2, paste0, "%")
hover_abund <- as.matrix(hover_abund)

hover_tax <- x[, 1:nsamp]
hover_tax[] <- paste0("\n \n<b>Phylum:</b> ", x$Phylum, "\n",
                   "<b>Class:</b> ", x$Class, "\n",
                   "<b>Order:</b> ", x$Order, "\n",
                   "<b>Family:</b> ", x$Family, "\n",
                   "<b>Genus:</b> ", x$Genus, "\n")
hover_tax <- as.matrix(hover_tax)

hovertext <- matrix(paste0(hover_strain, hover_abund, hover_tax),
                nrow = nrow(hover_tax), ncol = ncol(hover_tax))

# Perform log10 transformation on relative abundances
data <- log(x[, 1:nsamp], base = 10)
data[sapply(data, is.infinite)] <- NA
```
<br><br>

<div class="highlight">
### 1.2 High-resolution snapshot of community composition
</div>
Figure 2 is an interactive figure showing the microbial community composition at higher taxononomic resolution. Here, each row corresponds to a unique microbe.
<br><br>
You can interact with this figure by:

* Hovering the cursor over a cell to see that microbe's genus and species (and strain when available), relative abundance, and full taxonomic classification
* Clicking and dragging the cursor over a portion of the figure to zoom

<br><br>
```{r, out.height = "750px", echo = FALSE}
# Set sample names
#colnames(data) <- c("EB_269 (saliva)", "EB_270 (CapScan)", "EB_271 (CapScan)",
#                    "EB_272 (CapScan)", "EB_273 (CapScan)", "EB_274 (stool)")

# Prepare taxonomy row side
row_side <- x %>% select(Phylum)
row_side$Phylum[row_side$Phylum %!in% major_phy] <- "Other phyla"
row_side$Phylum <- factor(row_side$Phylum, levels = c("Other phyla",
                                                      "Proteobacteria",
                                                      "Bacteroidetes",
                                                      "Actinobacteria",
                                                      "Firmicutes"))

# Plot
pHeat <- heatmaply(data,
                   Rowv = FALSE,
                   Colv = FALSE,
                   colors = viridis::viridis(10),
                   row_side_colors = row_side,
                   row_side_palette = c("Actinobacteria" = "#FFB724",
                                        "Bacteroidetes" = "#64C62A",
                                        "Firmicutes" = "#072AC8",
                                        "Proteobacteria" = "#E93B4F",
                                        "Other phyla" = "#832CFF"),
                   subplot_margin = 0.01,
                   subplot_widths = c(0.9, 0.07),
                   side_color_colorbar_len = 0.3,
                   plot_method = "plotly",
                   custom_hovertext = hovertext,
                   xlab = "<b>Sample</b>",
                   ylab = "<b>Microbe</b>",
                   colorbar_xpos = 1.019,
                   colorbar_ypos = 0.5,
                   colorbar_len = 0.3) %>%
  layout(xaxis = list(showgrid = FALSE),
         yaxis = list(showgrid = FALSE,
                      showticklabels = FALSE),
         font = list(family = "Arial")) %>%
  colorbar(title = "Relative abundance",
           tickvals = c(-1, 0, 1),
           ticktext = c("0.1%", "1%", "10%"))

# Format row side
pHeat$x$layout$xaxis2$ticktext <- "Phylum"
pHeat$x$layout$xaxis$linecolor <- "#000000"
pHeat$x$layout$xaxis2$linecolor <- "#000000"
pHeat$x$layout$yaxis$linecolor <- "#000000"
pHeat$x$layout$legend$yanchor <- "bottom"
pHeat
```
**Figure 2:** Heat map showing relative abundance of microbes in each sample (N = 266 total identified). Each row corresponds to a unique microbe and each column corresponds to an individual sample. Note the relative abundance colorscale is in log units.

<br><br>

<div class="highlight">
### 1.3 Notable microbes detected
</div>

* *Bacteroides*:
  * Production of proteases from a few different species linked to gut inflammation, such as *Bacteroides vulgatus* (Mills *et al*., 2022) and *Bacteroides fragilis* (Wu *et al*., 2009)
  * <u>Note:</u> Genera *Bacteroides* and *Phocaeicola* are very closely related, with a recent reclassification of some *Bacteroides* as *Phocaeicola* (García-López *et al*., 2019). There are conflicting taxonomic assignments in this dataset (*e.g.*, genus identified as *Phocaeicola* but strain listed under *Bacteroides*) -- to help interpretation, regard *Bacteroides* and *Phocaeicola* as **one** genus.
<br><br>


<div class="highlight">
### 1.4 References
</div>

García-López, M., Meier-Kolthoff, J.P., Tindall, B.J., Gronow, S., Woyke, T., Kyrpides, N.C., *et al*. (2019) Analysis of 1,000 Type-Strain Genomes Improves Taxonomic Classification of *Bacteroidetes*. *Front Microbiol* **10:** https://doi.org/10.3389/fmicb.2019.02083.
<br><br>
Mills, R.H., Dulai, P.S., Vázquez-Baeza, Y., Sauceda, C., Daniel, N., Gerner, R.R., *et al*. (2022) Multi-omics analyses of the ulcerative colitis gut microbiome link *Bacteroides vulgatus* proteases with disease severity. *Nat Microbiol* **7:** 262–276.
<br><br>
Wu, S., Rhee, K.J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.R., *et al*. (2009) A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. *Nat Med* **15:** 1016–1022.